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Claims Associated with US Patent (Equizen, CanineZen)

Updated: Mar 4


The following will summarize the claims associated with the US Patent owned by Medifoods. The patent claims to be a medical treatment for disease of mammals affecting the heart, as well as functional deterioration associated with aging. Specifically, dogs, cats and horses are described. Along with that, there is claim to improving neuromuscular function, in addition to improved athletic performance. The following is the exact contents of the claims of the patent.

Description

CROSS REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of U.S. application Ser. No.

We claim:

1. A method of medical treatment of a disease, disorder or abnormal physical state in a mammal selected from the group consisting of heart disease and functional deterioration associated with ageing, the method comprising administering to a mammal an effective amount of a carrier and a nutritional supplement comprising L-Carnitine or its functional analogue, Coenzyme Q10 (Ubiquinone) or its functional analogue and Taurine or a Taurine precursor in a single or divided daily dose.

2. The method of claim 1, wherein the method comprises administering to a mammal an effective amount of a carrier and a nutritional supplement comprising L-Carnitine, Coenzyme Q10 (Ubiquinone) and Taurine or a Taurine precursor in a single or divided daily dose.

3. The method of claim 1, wherein the mammal is selected from the group consisting of a human, a dog, a cat and a horse.

4. The method of claim 1, wherein the disease, disorder or abnormal physical state comprises a disease, disorder or abnormal physical state that is due in whole or in part to aging.

5. A method of increasing neuromuscular or athletic performance in a mammal, the method comprising administering to the mammal an effective amount of a carrier and a nutritional supplement comprising L-Carnitine or its functional analogue, Coenzyme Q10 (Ubiquinone) or its functional analogue and Taurine or a Taurine precursor in a single or divided daily dose.

6. The method of claim 5, wherein the method comprises administering to the mammal an effective amount of a carrier and a nutritional supplement comprising L-Carnitine, Coenzyme Q10 (Ubiquinone) and Taurine or a Taurine precursor in a single or divided daily dose.

7. The method of claim 5, wherein the mammal is selected from the group consisting of a human, a dog, a cat and a horse.

8. The method of claim 7, wherein the mammal is a human.

9. The method of claim 2, wherein the mammal is selected from the group consisting of a human, a dog, a cat and a horse.

10. The method of claim 2, wherein the disease, disorder or abnormal physical state comprises a disease, disorder or abnormal physical state that is due in whole or in part to aging.

11. The method of claim 6, wherein the mammal is selected from the group consisting of a human, a dog, a cat and a horse.

12. The method of claim 3, wherein the mammal is a human.

13. The method of claim 9, wherein the mammal is a human.

14. The method of claim 1, wherein the disease, disorder or abnormal physical state comprises heart failure.

15. The method of claim 2, wherein the disease, disorder or abnormal physical state comprises heart failure.


The following summary of scientific citations is taken directly from the patent as well.


Cited Patent

Filing date

Publication date

Applicant

Title

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May 6, 1997

Reliv International, Inc.

Weight loss composition for burning and reducing synthesis of fats

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Aug 3, 1998

Apr 20, 1999

Advanced Micro Devices, Inc.

Gas shielding during plating

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Jan 6, 1998

Oct 26, 1999

Howard; James R.

L-carnitine, acetyl-L-carnitine, and pantothenic acid or ubiquinone, combined for prevention and treatment of syndromes related to ineffective energy metabolism

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May 16, 1996

Oct 26, 1999

Fuchs; Norbert

Dietetical combination preparations

* Cited by examiner

Non-Patent Citations

Reference

1

Abrahamsson, K., Eriksson, B.O., Holme, E., Jodal, U., Jonsson, A., Lindstedt, S. Pivalic Acid-Induced Carnitine Deficiency and Physical Exercise in Humans. Metabolism: Clinical & Experimental, 45 (12) : 1501-7, Dec. 1996.

2

Anand, I., Chandrashekhan, Y., De Giuli, F., Pasini, E., Mazzoletti, A., Confortini, R., Ferrari, R. Acute and Chronic Effects of Propionyl-L-Carnitine on the Hemodynamics, Exercise Capacity, and Hormones in Patients with Congestive Heart Failure. Cardiovascular Drugs & Therapy. 12 (3) : 291-9, Jul. 1998.

3

Brass, E.P., Hiatt, W.R. The Role of Carnitine and Carnitine Supplementation During Exercise in Man and in Individuals with Special Needs. Journal of the American College of Nutrition, 17 (3) : 207-15, Jun. 1998.

4

Brevetti, G., Di Lisa, F., Perna, S., Menabo, R., Barbato, R., Martone, V.D., Siliprandi, N. Carnitine-Related Alterations in Patients with Intermittent Claudication: Indication for a Focused Carnitine Therapy, Circulation, 93 (9) : 1685-9, May 1996.

5

Brevetti, G., Fanin, M., De Amicis, V., Carrozzo, R., Di Lello, F., Martone, V.D., Angelini, C. Changes in Skeletal Muscle Histology and Metabolism in Patients Undergoing Exercise Deconditioning: Effect of propionyl-L-carnitine. Muscle & Nerve, 20 (9) :1115-20, Sep. 1997.

6

Constantin-Teodosiu, D., Howell, S., Greenhaff, P.L. Carnitine Metabolism in Human Muscle Fiber Types During Submaximal Dynamic Exercise. Journal of Applied Physiology, 80 (3) :1061-4, Mar. 1996.

7

Gleim, G.G., Glace, B. Carnitine as an Ergogenic Aid in Health and Disease [editorial; comment]. Journal of the American College of Nutrition, 17 (3) : 203-4, Jun. 1998.

8

Heinonen, O.J. Carnitine and Physical Exercise. Sports Medicine, 22 (2) : 109-32, Aug. 1996.

9

Kaikkonen, J., Kosonen, L., Nyyssonen, K., Porkkala-Sarataho, E., Salonen, R., Korpela, H., Salonen, J.T. Effect of Combined Coenzyme Q10 and d-alpha-tocopheryl Acetate Supplementation on Exercise-Induced Lipid Peroxidation and Muscular Damage: A Placebo-Controlled Double-Blind Study in Marathon Runners.. Free Radical Research, 29 (1) : 85-92, Jul. 1998.

10

Lee, PJ, Harrison, EL, Jones MG, Chalmers RA, Leonard JV, Whipp BJ, "Improvement in exercise tolerance in isovaleric acidaemia with L-carnitine therapy" Journal of Inherited Metabolic Disease. 21(2):136-140, Apr. 1998.

11

Sole, M.J., Jeejeebhoy, K.N., abstract, The Failing Heart as a Starved Organ: Role of Nutrition in Heart Failure, Mar. 1998, Ottawa, Canada.

12

Sole, M.J., Keith, M., Ball, A., Kurian, R., Jeejeebhoy, K.N. Cardiovascular Pharmacology (The Failing Myocardium is Nutritionally Deficient). Journal of Cardiac Failure vol. 5 No. 3 Suppl. Sep. 1, 1999.

13

Sole, M.J., presentation slides, Heart Failure Society of America, 2nd Annual Meeting, Boca Raton, Florida, "The Fifth Paradigm: A New Look at Heart Failure", Sep. 1998.

14

Spina, RJ, Chi, MM, Hopkins MG, Nemeth, PM, Lwory, OH, Holloszy, JO, "Mitochondrial enzymes in crease in muscle in response to 7-10 days of cycle exercise.".

15

Svesson, M., Malm C., Tonkonogi, M., Ekblom, B., Sjodin, B., Sahlin, K. Effect of Q10 Supplementation on Tissue Q10 Levels and Adenine Nucleotide Catabolism During High-Intensity Exercise. International Journal of Sport Nutrition, 9 (2) : 166-80, Jun. 1990.

16

Thompson, C.H., Irish, A.B., Kemp, G.J., Taylor, D.J, Radda, G.K. The Effect of Propionyl-L-carnitine on Skeletal Muscle Metabolism in Renal Failure. Clinical Nephrology, 47 (6) :372-8, Jun. 1997.

17

Vasankari, T.J., Kujala, U.M., Vasankari, T.M., Vuorimaa, T., Ahotupa, M. Increased Serum and Low-Density-Lipoprotein Antioxidant Potential After Antioxidant Supplementation in Endurance Athletes. American Journal of Clinical Nutrition, 65 (4) :1052-6, Apr. 1997.

18

Vukovich, M.D., Sharp, R.L., Kesl, L.D., Schaulis, D.L., King D.S. Effects of a Low-Dose Amino Acid Supplement on Adaptations to Cycling Training and Untrained Individuals. International Journal of Sport Nutrition, 7 (4) : 298-309, Dec. 1997.

19

Weston, S.B., Zhou, S., Weatherby, R.P., Robson, S.J. Does Exogenous Coenzyme Q10 Affect Aerobic Capacity in Endurance Athletes?International Journal of Sport Nutrition, 7 (3) : 197-206, Sep. 1997.

Referenced by

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Filing date

Publication date

Applicant

Title

US6342526 *

Jan 12, 2001

Jan 29, 2002

Lonza Ltd.

Method for enhancing or achieving training-induced bradycardia with Carnitine

US6465517 *

Jul 11, 2000

Oct 15, 2002

N.V. Nutricia

Composition for the treatment of migraine

US6652891

Dec 12, 2001

Nov 25, 2003

Herbasway Laboratories, Llc

Co-enzyme Q10 dietary supplement

US6814972 *

Feb 20, 2001

Nov 9, 2004

Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.

Composition for prevention and/or treatment of vascular diseases, comprising propionyl L-carnitine and coenzyme Q10

US7169385

Mar 3, 2004

Jan 30, 2007

Ronald G. Udell

Solubilized CoQ-10 and carnitine

US7273606

Aug 18, 2005

Sep 25, 2007

Soft Gel Technologies, Inc.

Solubilized CoQ-10 and carnitine

US7345190 *

Nov 12, 2004

Mar 18, 2008

Ssv Therapeutics, Inc.

Carnitine conjugates as dual prodrugs and uses thereof

US7713523

Sep 24, 2007

May 11, 2010

Soft Gel Technologies, Inc.

Solubilized CoQ-10 and carnitine

US7777071

Aug 11, 2006

Aug 17, 2010

Ssv Therapeutics, Inc.

Production of carnitine conjugate intermediates

US8105583

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Jan 31, 2012

Soft Gel Technologies, Inc.

Solubilized CoQ-10

US8124072

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Feb 28, 2012

Soft Gel Technologies, Inc.

Solubilized CoQ-10

US8147826

Sep 9, 2005

Apr 3, 2012

Soft Gel Technologies, Inc.

Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene

US8148325

Dec 30, 2005

Apr 3, 2012

Hill'S Pet Nutrition, Inc.

Methods for enhancing the quality of life of a senior animal

US8252742

Jul 18, 2008

Aug 28, 2012

Hill'S Pet Nutrition, Inc.

Methods for enhancing the quality of life of a senior animal

US8343541

Mar 14, 2008

Jan 1, 2013

Soft Gel Technologies, Inc.

Ubiquinol and alpha lipoic acid compositions

US20110160299 *

Dec 23, 2010

Jun 30, 2011

Hill'S Pet Nutrition, Inc.

Composition and method

WO2009073659A1 *

Dec 2, 2008

Jun 11, 2009

Cpc (Tianjin) Fine Chemicals Co., Ltd.

Compositions comprising coenzyme q-10 and garlic oil for an increased coenzyme q-10 bioavailability

WO2009073661A2 *

Dec 2, 2008

Jun 11, 2009

Cpc (Tianjin) Fine Chemicals Co., Ltd.

Compositions comprising coenzyme q-io and garlic oil for an increased coenzyme q-10 bioavailability

WO2010103545A2 *

Mar 12, 2010

Sep 16, 2010

Viridis Biopharma Pvt Ltd,

Method of use of vitamin k as energy enhancer in diverse disease states

* Cited by examiner

Classifications

U.S. Classification

514/561, 514/578

International Classification

A61K31/205, A23L1/29

Cooperative Classification

A23L1/296, A23L1/29, A23V2002/00, A61K31/205

European Classification

A61K31/205, A23L1/29, A23L1/29F

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