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EquiZen. The Science

Claims Associated with US Patent (Equizen, CanineZen)

The following will summarize the claims associated with the US Patent owned by Medifoods. The patent claims to be a medical treatment for disease of mammals affecting the heart, as well as functional deterioration associated with aging. Specifically, dogs, cats and horses are described. Along with that, there is claim to improving neuromuscular function, in addition to improved athletic performance. The following is the exact contents of the claims of the patent. continue reading

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The Science Behind the Formula

The doctors researching congestive heart failure (CHF) identified a series of nutritional deficiencies in the heart muscle, and subsequently their research found that correction of the nutritional deficiencies (through daily supplementation) actually REVERSED the pathology of the heart muscle, seen in CHF. Subsequently, their research also showed a performance enhancement effect in people, animals, and athletes. But how does that happen without drug? Let me explain.


Clinical use of L-carnitine

LC is an essential cofactor of carnitine palmitoyl transferanse 1 (CPT1), allowing fatty acid transport into mitochondria and the incorporation of long chain fatty acids into the β-oxidation cycle to obtain acetyl-CoA. LC not only plays an important role in fatty acid metabolism, but also in glucose metabolism through its role in modulating the intramitochondrial acetyl-CoA/CoA ratio and the pyruvate dehydrogenase complex (PDH) (Figure 1).5,6

Regulation by LC of the supply of energy is especially important in heart tissue.7 Moreover, cardiovascular diseases, such as heart failure and ischemia, are frequently accompanied by decreased myocardial ATP levels leading to lower mechanical work efficiency.8 Thus LC and its derivatives have been considered for use in metabolic therapies which may help cardiomyocytes meet their absolute need for ATP, preserve the pulsatile cardiac function, and maintain cell and tissue viability.9–11

Another well recognized physiological role of LC is to increase the efflux of acyl and acetyl groups (such as the acyl-carnitines and acetyl-carnitine, respectively) out of on

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